2004 Pocket Book of Infectious Disease Therapy by John G. Bartlett

By John G. Bartlett

Designed to supply easy access to the criteria with which to struggle infectious sickness by means of concentrating on choice, right doses, bills, and unwanted side effects of antimicrobial brokers, the 2004 notebook of Infectious ailment Therapy attracts largely from techniques made by way of the facilities for illness keep watch over, the scientific Letter, the yank sanatorium Formulary provider, and the AMA's Drug reviews. Tabular fabric has been up to date to incorporate all newly authorized antibiotics, in addition to new thoughts for management.

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3 kg (height in inches–60 inches). 4 (actual weight in kg -IBW). b. Maintenance dose: Cockcroft-Gault equation. 3. MONITORING: Measure peak levels at 1 hr after start of 20- to 30-min infusion. Goal with q8h dosing is 5–10 Cg/mL for gentamicin and tobramycin or 20–40 Cg/mL for amikacin; peak levels when using low doses of gentamicin or tobramycin for synergy vs staph, strep or enterococcus is 3 Cg/mL. Monitor for nephrotoxicity with serum creatinine qd or qod. Monitor for ototoxicity when feasible in patients treated >3 days with periodic Romberg's sign and with reading an eye chart after rapid head movements.

7 ? 4 ? 25–1 g q6h Usual Usual Usual Chloroquine Renal and metabolized 48–120 ? 5–1 g q12h Cycloserine Renal 8–12 ? 5 g q6h — Usual Usual Usual Dirithromycin Bile 30–44 30–44 500 mg/d — Usual Usual Usual Doxycycline Renal and gut 14–25 15–36 100 mg bid 100 mg bid Usual Usual Usual Enoxacin Renal and hepatic 3–6 — 200–400 mg bid — Usual 1/2 usual dose 1/2 usual dose Ertapenem Renal and hepatic 4 ? 5 mg q12h Interferon alpha Nonrenal 2–3 Same ? 3 35 500 mg q24h 500 mg q24h Usual 250 mg q24h 250 mg q48h Linezolid Nonrenal 5–7 5–7 600 mg bid 600 mg bid Usual Usual Usual Lomefloxacin Renal 8 45 400 mg q24h — Usual 400 mg; then 200 mg qd Unknown Loracarbef Renal 1 32 200–400 mg q12h — Usual 200–400 mg q24h 200–400 mg 5d Mefloquine Hepatic 2–4 wk 2–4 wk 1250 mg × 1 250 mg q wk — Usual Usual Usual Meropenem Renal 1 — 1 g q8h Usual 500 mg q12h Methenamine hippurate mandelate Renal Renal 3–6 3–6 Methicillin Renal(hepatic) Metronidazole ?

5 Cg/mL Amikacin:<5 Cg/mL 3. 41 C. 5 —1–3 g q4–6h Usual usual Usual Usual 1–2 g IV q8h 1–2 g IV q 12h g q6h Ampicillin-sulbactam Renal 1 8–12 — 1–2 g q6h 1–2 g IV q8h 1–2 g IV q8h 1–2 g IVq12h Atovaquone Gut 70 70 750 mg bid susp — Usual Usual Unknown Atovaquone +proguanil Urinary 70 ? 7 ? 4 ? 25–1 g q6h Usual Usual Usual Chloroquine Renal and metabolized 48–120 ? 5–1 g q12h Cycloserine Renal 8–12 ? 5 g q6h — Usual Usual Usual Dirithromycin Bile 30–44 30–44 500 mg/d — Usual Usual Usual Doxycycline Renal and gut 14–25 15–36 100 mg bid 100 mg bid Usual Usual Usual Enoxacin Renal and hepatic 3–6 — 200–400 mg bid — Usual 1/2 usual dose 1/2 usual dose Ertapenem Renal and hepatic 4 ?

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