By John G. Bartlett
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Additional resources for 2004 Pocket Book of Infectious Disease Therapy
3 kg (height in inches–60 inches). 4 (actual weight in kg -IBW). b. Maintenance dose: Cockcroft-Gault equation. 3. MONITORING: Measure peak levels at 1 hr after start of 20- to 30-min infusion. Goal with q8h dosing is 5–10 Cg/mL for gentamicin and tobramycin or 20–40 Cg/mL for amikacin; peak levels when using low doses of gentamicin or tobramycin for synergy vs staph, strep or enterococcus is 3 Cg/mL. Monitor for nephrotoxicity with serum creatinine qd or qod. Monitor for ototoxicity when feasible in patients treated >3 days with periodic Romberg's sign and with reading an eye chart after rapid head movements.
7 ? 4 ? 25–1 g q6h Usual Usual Usual Chloroquine Renal and metabolized 48–120 ? 5–1 g q12h Cycloserine Renal 8–12 ? 5 g q6h — Usual Usual Usual Dirithromycin Bile 30–44 30–44 500 mg/d — Usual Usual Usual Doxycycline Renal and gut 14–25 15–36 100 mg bid 100 mg bid Usual Usual Usual Enoxacin Renal and hepatic 3–6 — 200–400 mg bid — Usual 1/2 usual dose 1/2 usual dose Ertapenem Renal and hepatic 4 ? 5 mg q12h Interferon alpha Nonrenal 2–3 Same ? 3 35 500 mg q24h 500 mg q24h Usual 250 mg q24h 250 mg q48h Linezolid Nonrenal 5–7 5–7 600 mg bid 600 mg bid Usual Usual Usual Lomefloxacin Renal 8 45 400 mg q24h — Usual 400 mg; then 200 mg qd Unknown Loracarbef Renal 1 32 200–400 mg q12h — Usual 200–400 mg q24h 200–400 mg 5d Mefloquine Hepatic 2–4 wk 2–4 wk 1250 mg × 1 250 mg q wk — Usual Usual Usual Meropenem Renal 1 — 1 g q8h Usual 500 mg q12h Methenamine hippurate mandelate Renal Renal 3–6 3–6 Methicillin Renal(hepatic) Metronidazole ?
5 Cg/mL Amikacin:<5 Cg/mL 3. 41 C. 5 —1–3 g q4–6h Usual usual Usual Usual 1–2 g IV q8h 1–2 g IV q 12h g q6h Ampicillin-sulbactam Renal 1 8–12 — 1–2 g q6h 1–2 g IV q8h 1–2 g IV q8h 1–2 g IVq12h Atovaquone Gut 70 70 750 mg bid susp — Usual Usual Unknown Atovaquone +proguanil Urinary 70 ? 7 ? 4 ? 25–1 g q6h Usual Usual Usual Chloroquine Renal and metabolized 48–120 ? 5–1 g q12h Cycloserine Renal 8–12 ? 5 g q6h — Usual Usual Usual Dirithromycin Bile 30–44 30–44 500 mg/d — Usual Usual Usual Doxycycline Renal and gut 14–25 15–36 100 mg bid 100 mg bid Usual Usual Usual Enoxacin Renal and hepatic 3–6 — 200–400 mg bid — Usual 1/2 usual dose 1/2 usual dose Ertapenem Renal and hepatic 4 ?