By Larry McWilliams
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The labeling in the latter is of varying intensity, but positive throughout. Type III collagen is detected in all investigated sections of the tendon. In some cases, the bone in the enthesis region also shows positive labeling. The antibody that detects type VI collagen, 5C6, demonstrates positive labeling in all investigated sections of the tendon. The labeling does not show any discernible regional differences in the region of the enthesis, where the chromogen precipitate is somewhat stronger.
1996). It is therefore difﬁcult to estimate, whether our specimens may perhaps represent an early stadium of degeneration of these parts of the tendons that cannot be diagnosed with conventional morphological methods. Strikingly, it is predominantly the ﬁbrocartilage cells that are positive, whereas the remaining parts of the tendons always are free from any labeling. If one applies the interpretation of labeling for 3B3- that has been outlined above, this might signify that degenerative alterations become ﬁrst manifest in the ﬁbrocartilages and only do so much later in the remaining tendinous tissue.
1998). At both sites, chondroitin 6 sulfate and type II collagen are typical markers of the ﬁbrocartilaginous phenotype; and in either joint the occurrence of type II collagen is particularly characteristic of the extensor tendon of the index ﬁnger. Despite the higher torque (due to the longer lever) of the extensor tendons in the region of the MCP joints (Littler and Thompson 1987) and despite the relative independence of movement of the MCP joints in various gripping functions of the hand, there is no more distinct ﬁbrocartilage present in the extensor tendons than there is in the region of the PIP joints.