By Maria-Jesfis Cornejo 1., Diane Luth 2, Kathleen M. Blankenship 3, Olin D. Anderson and Ann E. Blechl
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8 Tenocytes aligning along the fibre bundle axis. 9 Rope-like structures of electrospun PCL bundles: (a) plaited fibre, (b) twisted fibre. 3 Rope-like structures The scaffold proposed to act as a replacement structure for tendons is a number of these fibrous bundles grouped together in one of two ways. A plaited structure is one of these methods, and is formed by interweaving three fibrous bundles with each other (Fig. 9(a)). The other method creates a twisted fibre structure, whereby three fibrous bundles are twisted tightly together (Fig.
5 Scanning electron micrographs for (a) electrospun nanofibrous scaffold; and this scaffold with seeded (b) fibroblasts, (c) osteoblasts and (d) tenocytes. All cell micrographs are post 12-day culture. For clarity, arrows indicate individual cells. increased when cells were seeded onto PCL fibres coated with collagen. , 2005). One of the more important advantages of a PCL-collagen-coated scaffold is that while the scaffold is superior in terms of biocompatibility, it also maintains its mechanical integrity, both of which increase the chances of a new, sustainable, tissue being formed.
Poly(lactic acid), PLA, is one of the most significant members of the degradable polymer family, which can be produced from abundant, naturally occurring sources such as corns, sugars or beetroot. Poly(glycolic acid), PGA, and poly(lactic acid), PLA, belong to the family of polyesters and are obtained via ring opening polymerisation. They are semi-crystalline in nature and their molecular weights can be varied by the method of synthesis. PLA or poly(lactic) acid is derived from lactic acid, which is a chiral molecule and can therefore exist as d and l isomers, the l-isomer being the biological metabolite.