By Andrew Hadley, Peter Soothill
The potent prevention, analysis, and administration of alloimmune cytopenias has turn into a workforce attempt regarding hematologists, obstetricians, pediatricians, immunologists, laboratory technicians, midwives, and learn scientists. This booklet has been written through specialists of their respective fields to collect the problems of pathogenesis, epidemiology, prevention, prognosis, and medical administration. This accomplished yet obtainable account is commonly cross-referenced to stress the hyperlinks among pathogenesis and scientific sequels, among epidemiology and the reason for screening courses, and among prognosis and healing intervention.
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Additional resources for Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn
The carbohydrate helps to stabilize the tertiary structure of the molecule and is required for IgG to bind to Fc␥ receptors. The carbohydrate is heterogeneous and IgG from diﬀerent individuals may contain diﬀerent amounts of galactose. In vitro, the amount of incorporated galactose may aﬀect antibody function. 49 The relevance of these observations to the pathogenesis of HDFN is not yet established. 45 The longer hinge region of IgG3 may confer to the molecule the ability to span the gap between negatively charged red cells and monocytes with greater eﬃciency than IgG1.
Diﬀerential expression of function-related antigens on newborn and adult monocyte subpopulations. Immunology, 89, 587–91. 70 Warmerdam PAM, van der Winkel JGJ, Gosselin EJ & Capel PJA (1990). Molecular basis for a polymorphism of human Fc␥RII (CD32). Journal of Experimental Medicine, 172, 19–25. 71 Denomme G, Ryan G & Fernandes B (1997). The Fc␥RIIa-His131 allotype is overexpressed in infants with ABO hemolytic disease of the newborn. Blood, 90, 472–3a. 72 Ravetch JV & Perussia B (1989). Alternative membrane forms of Fc␥RIII (CD16) on human NK cells and neutrophils, cell-type speciﬁc expression of two genes which diﬀer in single nucleotide substitutions.
4 Stott LM, Hall AM, Wilson DWL, Barker RN & Urbaniak SJ (1999). Helper T cell epitopes on the RhD protein – towards a peptide vaccine for prevention of Rh disease. Transfusion Medicine, 9 (suppl 1), 54. 5 Medearis AL, Hensleigh PA, Parks DR & Herzenberg LA (1984). Detection of fetal erythrocytes in maternal blood postpartum with the ﬂuorescence-activated cell sorter. American Journal of Obsterics and Gynecology, 148, 290–5. 6 Mollison PL, Engelfriet CP & Contreras M (1997). Blood Transfusion in Clinical Medicine, 9th edn.