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Alternative Toxicological Methods by Harry Salem, Sidney A. Katz

By Harry Salem, Sidney A. Katz

Bringing jointly the hot and suitable contributions of over a hundred twenty five scientists from undefined, govt, and academia in North the US and Western Europe, substitute Toxicological tools explores the improvement and validation of substitute, relief, and refinement possible choices (the 3Rs) to animal checking out. across the world well-known scientists current what has been comprehensive so far in constructing appropriate choices to standard animal toxicological evaluation and supply most likely new initiatives.

In over forty chapters, the ebook addresses 7 issues, starting with the validation and regulatory reputation of choices within the US, the united kingdom, and Western Europe. Then the e-book covers tools according to the mechanisms of eye inflammation on the ocular floor, dermal toxicity checking out, and assessing neurotoxicity. it is usually a case research within the use of possible choices to figure out the mechanism of sulfur mustard motion and discusses the function of transgenics and toxicokinetics within the improvement of other toxicity assessments. eventually the booklet provides contemporary options in choices, together with using archival information, and in silico techniques.

Focusing at the technological know-how and never the politics, replacement Toxicological equipment concisely discusses the appliance of cutting-edge equipment and explores state of the art study on the topic of constructing and validating choices to animal checking out. This publication will profit toxicologists, beauty chemists, pharmacologists, experimental biologists, dermatologists, ophthalmologists, and regulatory officials of their quest for employing the 3Rs to using animals in toxicological trying out of drug applicants, chemical compounds, and cosmetics.

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Alternative Toxicological Methods

Bringing jointly the hot and appropriate contributions of over one hundred twenty five scientists from undefined, govt, and academia in North the USA and Western Europe, substitute Toxicological tools explores the improvement and validation of substitute, aid, and refinement possible choices (the 3Rs) to animal trying out.

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S. Code, 2000). 1 Advisory Committee on Alternative Toxicological Methods Agency Decisions/Actions ICCVAM test method evaluation process.

S. Code, 2000). 1 Advisory Committee on Alternative Toxicological Methods Agency Decisions/Actions ICCVAM test method evaluation process.

Code, 2000). 1 Advisory Committee on Alternative Toxicological Methods Agency Decisions/Actions ICCVAM test method evaluation process.

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