An Introduction to Radiation Protection in Medicine (Series by Jamie V. Trapp, Tomas Kron

By Jamie V. Trapp, Tomas Kron

Combining elements of overall healthiness physics with drugs, An creation to Radiation defense in Medicine covers the heritage of the topic and the clinical events the place radiation is the device to diagnose or deal with human sickness. Encouraging novices to the sector to correctly and successfully functionality in a flexible and evolving paintings surroundings, it familiarizes them with the actual difficulties confronted throughout the software of ionizing radiation in drugs.

The textual content builds a basic wisdom base earlier than supplying sensible descriptions of radiation defense in drugs. It covers uncomplicated matters concerning radiation safeguard, together with the actual technology at the back of radiation safeguard and the radiobiological foundation of radiation security. The textual content additionally offers operational and managerial instruments for organizing radiation defense in a clinical place of work. next chapters shape the center of the booklet, concentrating on the perform of radiation defense in several clinical disciplines. They discover a number of person makes use of of ionizing radiation in a number of branches of drugs, together with radiology, nuclear drugs, exterior beam radiotherapy, and brachytherapy.

With contributions from skilled practising physicists, this ebook offers crucial information regarding facing radiation security within the speedily transferring and numerous surroundings of medicine.

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Extra resources for An Introduction to Radiation Protection in Medicine (Series in Medical Physics and Biomedical Engineering)

Example text

Prior to entering the cell division phase (M = mitosis) the cell checks if the cell is large enough to divide and if all DNA has been faithfully duplicated. If DNA damage is sensed, the cell will initiate a cell cycle arrest to respond to the damage. Response to damage can have different forms—the most important ones are apoptosis and repair. 14 It is characteristic for cells that sense they are damaged and are unable to repair. Apoptosis is a type of cell suicide that prevents DNA damage to be passed on to future cell generations.

It also varies more between different cell lines and is often defective in cancer cell lines. On the other hand, HR is more predominant in highly proliferate cells that go through the S phase more often. This makes sense in the context of early embryonic development where efficiency of repair is less important than correctness. HR is also responsible for the different radiation sensitivity of cells in different parts of the cell cycle. Cells are most sensitive to radiation in the M phase and most radiation resistant in the late S phase.

3 Structure of DNA: The DNA is coiled around histones that form nucleosomes. These are structured in chromatin fibers that form—in irregular spirals—the chromosomes. 4. To make matters more complicated, DNA configuration will change throughout the cell cycle, where DNA is doubled in the S (synthesis) phase before dividing in the M (mitosis) phase. 5 shows the cell cycle, which will be discussed in more detail below. Finally, even when not cycling, the DNA must change geometric conformation to allow transcription of genes.

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