By Gunter Weiss, Victor R. Gordeuk, Chaim Hershko
This booklet summarizes the most up-tp-date study at the anemia of continual disorder and identifies potent diagnostic suggestions for this universal scientific condition-covering key issues with regards to the layout and choice of healing strategies together with the therapy of the underlying affliction, the biology of erythropoietin and the legislation of erythropoiesis, the disturbance of iron homeostasis, and the complicated nature of the systemic inflammatory reaction.
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Extra resources for Anemia of Chronic Disease (Basic and Clinical Oncology)
Defective expression of hephaestin in hemizygous male sex-linked anemia (sla) mice is also associated with microcytic anemia due to inefficient iron delivery to the circulation (56). 12 Pantopoulos The important function of ceruloplasmin in body iron metabolism is evident by the severe iron overload associated with human aceruloplasminemia (61,62). This disorder is characterized by normal Tf saturation, poor response to venesection therapy due to ensuing anemia, iron loading of macrophages and, notably, iron deposition in the brain (42), which does not occur in other forms of hemochromatosis.
The molecular basis of this Regulation of Iron Metabolism 9 important physiological process remained obscure for long time and only recently (in the last 5–6 years) we began to understand some fundamental mechanistic aspects. The turning point was the identification and characterization of molecules involved in the absorption of inorganic iron in mice. These include novel iron transporters and oxidoreductases, which are also conserved in humans. It should, however, be noted that we still do not know much on the absorption of heme, which in humans may represent a quantitatively more significant fraction of nutritional iron.
Interestingly, IDA is the most common nutritional pathologic condition, affecting $20% of world population, and poses a 6 Pantopoulos Figure 2 Iron distribution in the adult body. The vast majority ($60–70%) of iron is utilized in hemoglobin within bone marrow cells and circulating erythrocytes and is recycled by reticuloendothelial macrophages. A significant portion ($7–8%) of iron is utilized in muscle hemoglobin and the rest ($20–30%) is stored in the liver parenchyma. Daily absorption of 1–2 mg iron from the diet offsets nonspecific iron losses.