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Aplastic Anemia: Pathophysiology and Treatment by Hubert Schrezenmeier, Andrea Bacigalupo

By Hubert Schrezenmeier, Andrea Bacigalupo

This e-book takes account of the newest findings in laboratory learn and scientific trials to supply a entire and updated reference at the pathophysiology, epidemiology, prognosis and remedy of obtained and inherited aplastic anemia. in addition to offering an in depth evaluate of the pathophysiology of the illness, the foreign staff of authors covers all facets of administration, together with the validated techniques of bone marrow transplantation and immunosuppressive remedy, new ways akin to using hematopoietic progress elements and escalated immunosuppression, and debatable concerns akin to stem mobile transplantation. additionally integrated is a vital foreign consensus rfile on remedy, and a last part concentrates at the inherited syndrome Fanconi's anemia. special remedy guidance are given, making this the definitive source for hematologists and different clinicians fascinated about the administration and supportive care of sufferers with aplastic anemia. Scientists attracted to bone marrow failure also will locate this a useful reference.

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Sample text

In contrast to previous studies, the mean SCF level in these 85 patients was 1098 Ϯ 358 pg/ml, which was similar to that of normal controls (1160 Ϯ 316 pg/ml); there was no significant correlation between peripheral blood counts and SCF levels. The mean SCF concentration in patients who received prednisolone with or without anabolic steroids at the time of sampling was significantly lower than in patients who did not receive these agents. We did not find any correlation between changes in SCF levels and the 27 28 Pathophysiology of acquired aplastic anemia response to immunosuppressive therapy.

R. (1995) Lineage-restricted recruitment of immature haematopoietic cells in response to erythropoietin after normal haematopoietic cell transfection with erythropoietin receptor. Experimental Haematology, 23, 645. Metcalf, D. (1988) In The molecular control of blood cells. London: Harvard University Press. , Slanicka-Krieger, M. et al. (1995) Persistent growth impairment of bone marrow stroma after antilymphocyte globulin treatment for severe aplastic anaemia and its association with relapse. European Journal of Haematology, 5, 255–61.

1991). 2. Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in 51 patients with aplastic anemia and no sign of infection and 12 normal controls. Each horizontal bar indicates the mean value in the group. , 1989). , 1996). 5 pg/ml) was sufficient to determine G-CSF levels in all AA patients and normal controls. 001). 01). There was a significant negative correlation between plasma G-CSF levels and absolute neutrophil counts (ANC) in AA patients with no signs of infection. The 51 patients were grouped on the basis of sex, age, interval between diagnosis and time of study entry, and type of therapy at the time of study entry.

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